Improved Characteristics of aPC-Resistance Assay:Coatest aPC Resistance by Predilution of Samples With Factor V Deficient Plasma
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چکیده
منابع مشابه
Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations.
Activated protein C (APC) resistance is a major risk factor for venous thrombosis. Factor V (FV) gene mutations like FV(Leiden) (R506Q) and FV(R2) (H1299R) may cause APC resistance either by reducing the susceptibility of FVa to APC-mediated inactivation or by interfering with the cofactor activity of FV in APC-catalyzed FVIIIa inactivation. We quantified the APC cofactor activity expressed by ...
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Human factor V is activated to factor Va by alpha-thrombin after cleavages at Arg709, Arg1018, and Arg1545. Factor Va is inactivated by activated protein C (APC) in the presence of a membrane surface after three sequential cleavages of the heavy chain. Cleavage at Arg506 provides for efficient exposure of the inactivating cleavages at Arg306 and Arg679. Membrane-bound factor V is also inactivat...
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introduction : activated protein c (apc) inactivates factor v by cleavage of its heavy chain at arg306, arg506, arg679, and lys994. mutational changes, which abolish apc cleavage sites, may predispose thrombosis by altering the inactivation process of factor v. factor v leiden (arg506glu) has been demonstrated as a strong risk factor for thrombosis. in the current study, we have studied whethe...
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To the Editor: 70 nmol/L, 35 nmoUL, 14 nmollL, 7 nmol/L, and 0 nmol/L APC, corresponding to loo%, 50%, 20%, lo%, and 0% factor Va inactivaResistance to activated protein C (APC). caused by a mutated tion, respectively. Here we will summarize our current experience Coagulation factor v (factor v Leiden), has been reported as a prediswith this modified functional assay for the detection of factor...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 1996
ISSN: 0002-9173,1943-7722
DOI: 10.1093/ajcp/106.5.588